SARS-CoV-2-Antigen-Main.png

ANTIGEN TEST KITS

SARS-COV-2 (ELISA)

COVID-19 RAPID TEST CASSETTE

The World Health Organization (WHO) on March 11 declared COVID-19 a pandemic, pointing to the over 4 million cases of the corona virus illness in over 110 countries and territories around the world and the sustained risk of further global spread. To stop further global spread of the virus, the world needs a screening test that is fast and reliable. We started to develop a rapid test cassette against the COVID-19.

HOUGH Pharma is proud to announce that we are one of the first companies with a rapid test for COVID-19 IgG/IgM. Our product is made with FDA/CE/TGA mark in order to to fulfill highest USA/European/Australian standards . Now worldwide our product is being used to screen patients for the coronavirus.

Video Instructions

HOW TO USE

Symptoms

OF COVID-19 PATIENT

Testing Technique

COMPARISON

Advantages

Disadvantages

PCR Detection

Mature technique 

Can be used for early diagnosis

Complex operation and high cost

High false negative rate

Antibody Detection

Simple operation

Low cost

Cannot be used for early
diagnosis

Antigen Detection

(Nasopharynx swab)

Early diagnosis

Easy operation

Less sensitive than nucleic

acid testing

False negative question

Main Mechanism of

ANTIGEN IN BLOOD

When SARS-CoV-2 invades the lung cells it will express a large amount of self protein to reassemble the virus particles causing cell damage and forming inflammation. The virus protein expressed in excess and the virus protein released from the disintegration of virus particles killed by the body in the lesions will enter the blood circulation through the vessel wall with increased permeability due to inflammation in the lesions. 

SARS-CoV-2-blood-antigen-Main-Mechanism.

Main Mechanism of

REDUCTION & ELMINATION

  • The virus antigen will stimulate the patient's body to produce the corresponding antibody, and the antibody produced by the body will produce the specific combination with the corresponding antigen, forming the antigen antibody immune complex to be cleared by the body's immune system. As the amount of antibody produced by the patient increases gradually, the amount of antigen cleared will also increase synchronously.

  • With the activation of the immune system, the ability of killing virus is enhanced, the viral load in the body will gradually decrease, and the production of virus and blood antigen will gradually decrease.

SARS-CoV-2-blood-antigen-Mechanism-Reduc

Schematic Diagram

ANTIGEN & ANTIBODY CHANGES IN BLOOD

Significance of Combined Detection

OF ANTIGEN & ANTIBODY IN BLOOD

  • The detection of antigens in blood can effectively make up for the "window period" of antibody detection.

  • The detection of antibody in blood can avoid the problem that antigen can not be detected in the middle and later stage of infection.

  • The combined detection of antigen and antibody in blood can verify each other at different disease stages, and provide complete serological evidence for the diagnosis of COVID-19.

Test Sensitivity

SARS-COV-2 ANTIGEN

Cut-off value=2.97pg/mL

Group

1

2

3

SUM

Days from onset

≤ 3

4 ~ 7 days

8 ~ 14 days

/

Total number of samples

30

38

28

96

Number of antigen positive samples

32

38

31

101

Sensitivity

93.4%

100%

90.3%

95.0%

  • Sample source: PCR confirmed COVID-19 patients serum samples

© 2020 Hough Pharma